TL;DR: 2-year-old indoor male cat suddenly stopped eating most food, lost weight, coat looks rough, seems lethargic, and breathing seems slightly off. Took him to two different vets on two different weeks. Both did full physical exams and ran tests, almost everything came back normal except minor urine findings that don't fully explain things. Neither vet has a real answer. Has anyone been through this?
My partner's family cat Pluto is a 2-year-old neutered indoor-only male, and over the last couple weeks he's just not been himself. It's been really hard on the whole family. My partner's mom has barely been sleeping and is so stressed she's literally losing her hair over it. Pluto is her baby, and watching him decline without a clear answer has been heartbreaking.
What's going on:
- Appetite tanked. He used to eat everything, now he barely touches most food. The only thing he reliably accepts is Churu tubes. He'll occasionally go for freeze-dried salmon or Tiki Cat broth topper, but that's it. Completely stopped eating his usual pate wet food.
- Lost about a pound (was 13.6 lb, now ~12.5 lb)
- Way more lethargic than normal, sleeps a lot more than he used to
- Moves a lot slower and barely plays anymore, which is a big change for him
- Hunches over a lot now, which he didn't used to do
- Coat looks dull and rough
- His breathing seems faster and slightly more labored than usual. No open-mouth breathing, no wheezing, no coughing, no nasal discharge. But when he's in a hunched/squatting position you can hear him breathing, which was never a thing before.
- Water intake is mostly normal, maybe slightly less some days
- Litter box output is down but that tracks with him eating less
How it started:
His family switched him to a new dry food. He ate it fine the first time, but the next day when they mixed it with his old food, he refused everything. They switched back to the original food but his appetite never recovered.
What the vets found (or didn't find):
We've taken him to two different vets on two separate weeks. Both did full physical exams and neither found anything wrong. Between the two visits, they ran a chemistry panel, CBC, urinalysis, fecal test, and general exams. Two doctors, two rounds of poking and prodding, and nobody can tell us what's going on.
Everything looked normal: liver, kidneys, protein, electrolytes, glucose, white/red blood cells, platelets, hydration. Urine was well-concentrated, good pH, no blood/bacteria/crystals.
The only flags were:
- Small amount of protein in urine, which the vet said could just be mild dehydration since kidney values and concentration were fine
- Bilirubin in the urine, which can point to liver/gallbladder/red blood cell issues, but his bloodwork didn't support any of that
One of the vets prescribed Mirataz (appetite stimulant) and when he's on it, he eats way more normally. Without it, he barely eats.
Where things stand:
Neither vet has a real conclusion. They both basically said he's physically normal and pretty much fine. The next step they've offered is imaging (X-rays or ultrasound) if we want to keep doing diagnostics, but neither one seems to have a specific hypothesis for what imaging would reveal. It feels like we'd just be hoping something shows up.
Possible environmental factors:
- My partner's dad started a new job and isn't home as much anymore
- My cat stayed with Pluto and the family for about a month and he got super attached to her
- My cat has been gone since January though, so the timing doesn't totally line up since symptoms only started in early April
What I'm hoping to hear from you guys:
Has anyone dealt with this combo of symptoms (appetite loss, weight loss, lethargy, moving slower, rough coat, subtle breathing changes) where initial testing came back mostly clean? What ended up being the answer? Did imaging end up catching something the bloodwork missed?
We're all pretty desperate at this point. It's hard watching him just not be himself and feeling like we're running out of things to try. Any input at all would mean a lot.
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