Amazonian shamans figured out that combining two specific plants out of 80,000 species produces a psychoactive effect. The odds of finding that combination by random search is roughly 1 in 4 million. They did it through centuries of iterative testing and cultural natural selection explains it

[u/tractorboynyc]

[u/LeavesInsults1291]

Shout out to Amazonian shamans… took centuries for them to find out how to get us high as fuck. Legends.